Studies of RNA Sequence and Structure Using Nanopores.
نویسندگان
چکیده
Nanopores are powerful single-molecule sensors with nanometer scale dimensions suitable for detection, quantification, and characterization of nucleic acids and proteins. Beyond sequencing applications, both biological and solid-state nanopores hold great promise as tools for studying the biophysical properties of RNA. In this review, we highlight selected landmark nanopore studies with regards to RNA sequencing, microRNA detection, RNA/ligand interactions, and RNA structural/conformational analysis.
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عنوان ژورنال:
- Progress in molecular biology and translational science
دوره 139 شماره
صفحات -
تاریخ انتشار 2016